The Belmont principle of beneficence requires that:

The Belmont principle of beneficence emphasizes the importance of maximizing benefits while minimizing potential harm to research subjects. This principle dictates that risks associated with research must be reasonable and justifiable when weighed against the anticipated benefits of the study. This ensures that participants are treated ethically, and their well-being is prioritized.

In this context, if the risks imposed on participants are excessive in relation to the possible benefits, the ethical integrity of the research is compromised. Hence, maintaining a balanced relationship between risk and benefit is fundamental to ethical research practices, aligning with the principle of beneficence.