What principle applies when a research proposal does not align with the original consent form?

The principle that applies when a research proposal does not align with the original consent form is that informed consent remains based on original intentions. This means that participants have the right to understand what they are consenting to in a study, including the specifics of what will be done with their data and the goals of the research. If the research deviates from what was outlined in the consent form, the participants may not be informed about the new aspects of the study, potentially compromising their autonomy and informed decision-making.

Therefore, it is crucial for researchers to ensure that any significant changes in the study are communicated to participants, and they should seek re-consent if necessary. This preserves the ethical principles of transparency and respect for participants' rights.

The focus on maintaining alignment with the original consent form emphasizes that participants' trust in the research process hinges on their understanding of what they originally agreed to, and any deviations from this can raise ethical concerns regarding the validity of the consent.