When must researchers submit COI disclosures to comply with PHS regulation?

Researchers must submit Conflict of Interest (COI) disclosures no later than the time of proposal submission to comply with Public Health Service (PHS) regulations. This requirement is in place to ensure that any potential financial interests or conflicts that could influence the research are identified and managed before the research begins. By submitting disclosures at the proposal stage, institutions can evaluate the potential impact of these interests on the research's integrity and ensure compliance with ethical standards prior to engaging in the work.

This early disclosure process supports transparency and helps mitigate possible biases that could affect research outcomes, ultimately aiming to protect the integrity of the research and maintain public trust. The requirement aligns with the PHS's focus on ensuring that researchers and institutions are accountable for managing any conflicts that may arise during the course of research activities.