Which concern is related to the Belmont Principle of Justice?

The Belmont Principle of Justice emphasizes the fair distribution of both the benefits and burdens of research. This principle is particularly relevant to vulnerable populations, such as prisoners, who may have limited autonomy and can be at risk of exploitation.

When considering option C, it highlights a significant ethical concern that arises when prisoners participate in research primarily for the benefit of society rather than their own. This can lead to a situation where the prisoners' involvement serves more to advance societal knowledge or goals rather than ensuring that they also gain direct benefits from their participation. This misalignment violates the justice principle, as it does not uphold the idea that all subjects should receive equitable treatment and benefits from the research activities.

Additionally, the concern regarding the rights and well-being of prisoners is crucial, given that they might be compelled to participate due to their circumstances rather than genuine consent, which could further illustrate the imbalance embedded in societal benefit over individual gain. Thus, this connection to the Belmont Principle of Justice makes option C the most relevant choice.